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Research Interests

Clilnical medicine

Human genetics & genomics

Health data science

Cardiovascular diseases

Epidemiology

Reproducible research

Skills

Data visualization

Biostatistics

High-performance computing

Bash

R

Python

Git version control

Snakemake

Disclaimer

Made with the R package pagedown.

Main

Albert Henry

I am a research fellow at University College London (UCL), UK. Previously, I did a PhD on Cardiovascular Genetics at UCL sponsored by the British Heart Foundation Cardiovascular Biomedicine 4-year PhD studentship. Prior to my PhD, I trained and practiced as a clinician (general practice) in Indonesia, and I had an MSc degree in Health and Biomedical Data Science from UCL. In my research, I am working at the intersection of data science, human genetics, and drug target validation within the field of cardiovascular diseases. My research interest is integrating computational methods, statistics, and data visualization to elucidate causal biology and to identify therapeutic targets for complex cardiovascular diseases using large-scale genetic and deep phenotype data.

Education

PhD, Cardiovascular Genetics

Institute of Cardiovascular Science

University College London, UK

2023 - 2018

  • Thesis: Understanding heart failure using human genetics

MSc, Data Science for Research in Health and Biomedicine

Institute of Health Informatics

University College London, UK

2017 - 2016

  • Dissertation: A Mendelian randomization study investigating the causal association between sleep duration and cognitive functions
  • Graduated with distincition
  • Listed in Faculty Dean’s List of Top Performing Students

MD

Diponegoro University

Semarang, Indonesia

2014 - 2007

  • Graduated cum laude

Professional Experience

Research fellow

Institute of Health Informatics

University College London, UK

current - 2022

  • Built a high-throughput computational pipeline and led the analysis for drug target validation using large-scale genomics and proteomics data

Visiting scientist

Broad Institute of MIT and Harvard

Cambridge, MA, USA

2022 - 2022

  • Visiting scientist at the Broad Institute Precision Cardiology Laboratory
  • Research project: Functional profiling of genomic loci for heart failure with singe-nuclei RNA sequencing

Research assistant

Institute of Health Informatics

University College London, UK

2018

  • Performed statistical analysis, data visualisation, and prepared manuscript for genome-wide association study meta-analysis of heart failure

Laboratory intern

Center for Biomedical Research

Semarang, Indonesia

2016

  • Performed DNA extraction and cytogenetic analysis

General practitioner

Puskesmas (public health centre) Ambarawa

Ambarawa, Indonesia

2015

  • Carried out GP services and health promotion programmes

Emergency room doctor

RSUD (district hospital) Ambarawa

Ambarawa, Indonesia

2014

  • Carried out emergency clinical services

Visiting medical student

Radboud University

Nijmegen, The Netherlands

2013

  • Studied Neglected Tropical Disease and International Public Health




Teaching Experience

Advanced Statistical Analysis & Advance Statistics in Records Research

Institute of Health Informatics

University College London, UK

current - 2020

Computational Genetics in Healthcare

Institute of Health Informatics

University College London, UK

2022 - 2021

  • Developed practical materials and served as teaching assistants.
  • Topics include Mendelian randomization, GWAS, Polygenic Risk Score, Rare-variant association analysis, and GWAS meta-analysis

Computational Methods in Biodiversity Research

Department of Genetics, Evolution and Environment

University College London, UK

2022 - 2021

  • Served as teaching assistants in introduction to data science and statistics with R

Introduction to data visualisation with R

Code Club

University College London, UK

2020

Training & Certifications

Computational Systems Biology for Complex Human Disease

Wellcome Genome Campus Advanced Courses

Cambridge, UK

2021

NVIDIA-DIRAC AI Bootcamp

University College London

University College London, UK

2019

Data Visualisation for Biology

European Bioinformatics Institute (EMBL-EBI)

Cambridge, UK

2019

Statistical Analysis of Genetic Association Studies

University of Liverpool

Liverpool, UK

2018

Exploring Human Genetic Variation

European Bioinformatics Institute (EMBL-EBI)

Cambridge, UK

2018

Understanding the genetic architecture of complex traitst through SNP-based heritability analysis

University College London

University College London, UK

2018

Genetic Association Studies and Mendelian Randomization

University College London

University College London, UK

2017

Talks

Genetic analysis in 1.9 million individuals reveals new insights into genetic variation underlying heart failure susceptibility

European Society of Human Genetics Conference

N/A

2023

  • Presented in oral session

Estimating the causal associations between plasma protetins and heart failure using Mendelian randomization

Workshop: Accelerating Precision Medicine with data science

Örsundsbro, Sweden

2020

  • Invited and sponsored by Olink Proetomics

Large-scale genome-wide association study of heart failure identifies novel susceptibility loci and provides a platform for drug target validation

EMBL Conference: Target Validation Using Genomics and Informatics

Heidelberg, Germany

2019

  • Presented in poster session

Sleep duration and cognition: Application of linear and non-linear Mendelian randomization in UK Biobank

South England Genetic Epidemiology Group (SEGEG) meeting

Oxford, UK

2019

Other activities

UCL Code Clubs

N/A

University College London, UK

current - 2019

  • Co-lead of UCL Code Clubs, a volunteer-led group based at UCL aiming to introduce and encourage good coding practice and reproducibility in computational research

The IHI Code Club Hackathon 2020+1

Institute of Health Informatics

University College London, UK

2021

  • Co-organise the IHI Code Club Hackathon 2020+1, a 3-day virtual collaborative public hackathon event to solve real-world issues in health data science

Grants & Awards

American Society of Human Genetics Annual Meeting 2023

N/A

Washington D.C., USA

2023

  • ASHG Trainee Research Excellence Award Winner (predoctoral category)

Indonesian Society of Human Genetics Annual Meeting 2023

N/A

Makassar, Indonesia

2023

  • Best oral presentation

UCL Access and Widening Participation Bespoke Project Awards

N/A

University College London, UK

2022

  • £3000 funding for ‘One Data Science’ project: introducing data science and statistics to A-level students across the UK

UCL eResearch Community-Based Initiatives 2021

N/A

University College London, UK

2021

  • £500 funding for UCL Code Clubs

UCL eResearch Community-Based Initiatives 2020

N/A

University College London, UK

2020

  • £500 funding for UCL Code Clubs

UCL Researcher-led Initiatives 2020

N/A

University College London, UK

2020

  • £1000 funding for IHI Code Club Hackathon

London Genetics Network inaugural meeting 2020

N/A

London, UK

2020

  • Best poster
  • Poster title: Mendelian randomization analysis of circulating protein levels for therapeutic target prioritization in heart failure

Alzheimer’s Indonesia conference 2017

N/A

Jakarta, Indonesia

2017

  • Best poster
  • Poster title: How sleep genes affect cognition – a Mendelian randomization study in UK Biobank

Selected Publications

Large-scale genome-wide association study of dilated cardiomyopathy in over one million participants identifies genes, pathways, and cellular communications contributing to pathology

Manuscript in review

N/A

2023

  • Sean Zheng, Albert Henry (joint first author), …

Genetic analysis in 1.9 million individuals provides insights into the causal aetiology underlying heart failure subtypes

Manuscript in review

N/A

2023

  • Albert Henry, …

Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity

Science Advances

N/A

2023

  • Amand F Schmidt, …, Albert Henry, …, Jessica van Setten, Chris Finan

The relationship between adiposity and cognitive function: a bidirectional Mendelian randomization study in UK Biobank

International Journal of Epidemiology

N/A

2023

  • Tom Norris, Antoine Salzmann, Albert Henry, Victoria Garfield, Snehal M Pinto Pereira

Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study

The Lancet Digital Health

N/A

2023

  • Valerie Kuan, …, Albert Henry, …, Harry Hemingway, Aroon D Hingorani

Coupled myovascular expansion directs cardiac growth and regeneration

Development

N/A

2022

  • Paige DeBenedittis, Anish Karpurapu, Albert Henry, …, R Thomas Lumbers, Ravi Karra

Therapeutic targets for heart failure identified using proteomics and Mendelian randomization

Circulation

N/A

2022

  • Albert Henry, María Gordillo-Marañón, Chris Finan, Amand F Schmidt, …, R Thomas Lumbers

The genomics of heart failure: design and rationale of the HERMES consortium

ESC Heart Failure

N/A

2021

  • R Thomas Lumbers, Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, Daniel I Swerdlow, …

Estimating the effect of reduced attendance at emergency departments for suspected cardiac conditions on cardiac mortality during the COVID-19 pandemic

Circulation: Cardiovascular Quality and Outcomes

N/A

2021

  • Michail Katsoulis, Manuel Gomes, Alvina G Lai, Albert Henry, Spiros Denaxas, Pagona Lagiou, Vahe Nafilyan, Ben Humberstone, Amitava Banerjee, Harry Hemingway, R Thomas Lumbers

Life-Time Covariation of Major Cardiovascular Diseases: A 40-Year Longitudinal Study and Genetic Studies

Circulation: Genomic and Precision Medicine

N/A

2021

  • Lars Lind, Johan Sundström, Johan Ärnlöv, Martin Ingelsson, Albert Henry, R Thomas Lumbers, Erik Lampa

Genetic and functional insights into the fractal structure of the heart

Nature

N/A

2020

  • Hannah V Meyer, … Albert Henry …, Ewan Birney, Declan P O’Regan

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Nature Communications

N/A

2020

  • Sonia Shah, Albert Henry (joint first authors), …, R. Thomas Lumbers

The relationship between sleep duration, cognition and dementia: a Mendelian randomization study

International Journal of Epidemiology

N/A

2019

  • Albert Henry, Michail Katsoulis, Stefano Masi, Ghazaleh Fatemifar, Spiros Denaxas, Dionisio Acosta, Victoria Garfield, Caroline E Dale